Monthly Archives: December 2020

Computational Pharmacology of Racetams

Today I will be discussing an interesting class of compounds referred to as racetams. Racetams are relatively simple molecules discovered over 60 years ago. Like many simple, aliphatic molecules with nitrogen incorporated, they have a distinct psychoactive effect. Looking at the physicochemical diversity among the five commercially available racetams I have studied, there is a […]

Computational Pharmacology

How a molecule interacts within a living organism is incredibly complicated. Even the simplest molecules can interact with over 25,000 protein products from genes (not including their splice variants) as well as a wide variety of lipids, sugars, nucleic acids, and their combinations distributed throughout the body. In a typical drug discovery effort, a narrow […]

Scaffold Hopping

I have always deeply believed that reading is the cornerstone of gaining knowledge. Through reading, we gain the wisdom and knowledge of others. I recently purchased a book titled “Scaffold hopping in medicinal chemistry” edited by Nathan Brown and published by Wiley VCH. It will be interesting to see my the change of my understanding […]