In medicinal chemistry, one often must compromise between absorption, distribution, metabolism, and excretion (ADME) properties and affinity to a certain biological target. This is often a great challenge due to the limited chemical combinations which can yield a high affinity molecule for a target… but what if you had a protein with a very wide […]
Monthly Archives: July 2020
When starting a new pharmaceutical chemistry project, there are several common approaches. In my opinion, the most interesting is to take a natural product with known therapeutic properties and begin modifying its structure. This strategy has yielded life saving, world changing medicines including the penicillin based family of antibiotics. Another strategy is to simply perform […]